A compound design to jointly estimate the target dose and its slope in the dose-toxicity function.

J. A. Moler Cuiral

In this work two designs are proposed to jointly estimate the slope and the target dose in the phase-I of a clinicial trial. We will focus on one of them: the c-compound design which incorporates two restrictions. The first one does not allow doses with toxicity larger than a chosen percentile, the second restriction guarantees an efficiency with respect to the c-optimal larger than "e"

Palabras clave: Experimental designs phase-I clinical trial

C. de la Calle Arroyo, M. Amo-Salas, J. López-Fidalgo, L. J. Rodríguez-Aragón

A. Muñoz del Río, V. Casero-Alonso, M. Amo-Salas